TīmeklisBackground: Lysosome-associated membrane protein type 2a (LAMP-2A) is the receptor for chaperone-mediated autophagy (CMA).Results: The transmembrane of … TīmeklisThe lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about 50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 or LAMP-2 are viable and fertile. However, mice deficient in both LAMP-1 and LAMP-2 have an embryonic lethal phenotype. T …
Recombinant Anti-LAMP2A antibody [EPR4207(2)] - Lysosome …
Tīmeklis2024. gada 7. nov. · LAMP2A possesses a highly glycosylated luminal region that is common to all LAMP2 isoforms and a specific 11-amino-acid-long cytosolic C … TīmeklisAccordingly, lysosomal LAMP2A levels were drastically reduced in nfe2l2-knockout hepatocytes, which also displayed a marked decrease in CMA activity. Oxidant challenge with paraquat or hydrogen peroxide, or pharmacological activation of NFE2L2 with sulforaphane or dimethyl fumarate also increased LAMP2A levels and CMA … day shift elenco
LAMP2A regulates the loading of proteins into exosomes
Tīmeklis2024. gada 12. nov. · Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of modified and oxidatively damaged proteins directly into the lumen of lysosomes for degradation and protein turnover. Elevated expression of LA … TīmeklisLAMP2 has 3 distinct isoforms, LAMP2A, 2B & 2C. Database link: P13473 (Peptide available as ab23322) 阳性对照 WB: Human liver tissue lysate. ICC: CaCo2 cells, … Tīmeklis2024. gada 25. marts · LAMP2A is required for the sorting of selected proteins into extracellular vesicles To investigate the impact of LAMP2A in exosome protein … day shift fandom